منابع مشابه
Teaching neuroimages: reversible paradoxical lithium neurotoxicity.
A 33-year-old man with bipolar affective disorder presented with acute onset of rigidity, tremors, and confusion. He had been taking oral lithium (1,200 mg daily) for the past 2 months. Baseline blood, EEG, and CSF analyses were normal. Serum lithium level was 0.67 mEq/L (0.3–1.3). GadoliniumMRI brain showed multiple bilateral symmetric T2-weighted hyperintensities (figure, A–C). On suspicion o...
متن کاملLithium neurotoxicity.
The peripheral and central neurotoxic effects of lithium carbonate are illustrated by 4 case histories. Lithium neurotoxicity is likely to be more common than the literature suggests. Neurological sequelae may be irreversible and may be associated with therapeutic serum levels. Prevention may be facilitated by more stringent case selection, EEG and clinical monitoring and the development of imp...
متن کاملLithium neurotoxicity.
Inspite of the advent of newer antimanic drugs, lithium carbonate remains widely used in the treatment and prevention of manic-depressive illness. However care has to be exercised due to its low therapeutic index. The central nervous system and renal system are predominantly affected in acute lithium intoxication and is potentially lethal. The more common side effect involves the central nervou...
متن کاملPathological Neurotoxicity with Lithium
Though lithium-induced neurotoxicity usually occurs when serum lithium exceeds 2.0 mEq/1, reports document its occurrence with serum lithium within the therapeutic range (Strayhorn and Nash 1977, Hansen and Amidsen, 1978, Speirs and Hirsch 1978, West and Meltzer 1979). Neurotoxicity has even been described with serum lithium between 0.4 and 0.5 mEq/1 (Hansen and Amidsen 1978). Such may best be ...
متن کاملLithium-induced Paradoxical Neurotoxicity-a Risk Factor
Though lithium-induced neurotoxicity usually occurs when serum lithium exceeds 2.0 mEq/1, reports and reviews document its occurence with serum lithium within the therapeutic range (Strayhorn and Nash 1977; Hansen and Amidsen 1978; Speirs and Hirsch 1978; West and Meltzer 1979). Neurotoxicity has even been described with serum lithium between 0.4 and 0.5 mEq/l (Hansen and Amidsen 1978). Many hy...
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ژورنال
عنوان ژورنال: The Primary Care Companion For CNS Disorders
سال: 2012
ISSN: 2155-7780
DOI: 10.4088/pcc.11r01197